منابع مشابه
Neuronal polarity.
The assembly of functional neuronal networks in the developing animal relies on the polarization of neurons, i.e., the formation of a single axon and multiple dendrites. Breaking the symmetry of neurons depends on cytoskeletal rearrangements. In particular, axon specification requires local dynamic instability of actin and stabilization of microtubules. The polarized cytoskeleton also provides ...
متن کاملNeuronal polarity in 2011.
Neurons appear to be the most highly polarized cell type in our bodies, often exhibiting a very long axon and highly branched dendrites. How neurons establish and maintain their morphological polarity has fascinated neuroscientists from the time of Cajal, but only recently have we begun to understand the molecular mechanisms that establish and maintain neuro-nal polarity, including both cell-ex...
متن کاملNeuronal Polarity and Trafficking
Among the most morphologically complex cells, neurons are masters of membrane specialization. Nowhere is this more striking than in the division of cellular labor between the axon and the dendrites. In morphology, signaling properties, cytoskeletal organization, and physiological function, axons and dendrites (or more properly, the somatodendritic compartment) are radically different. Such pola...
متن کاملKey Regulators in Neuronal Polarity
Neurons are highly polarized cells, most of which develop a single axon and several dendrites. These two compartments acquire specific characteristics that enable neurons to transmit intercellular signals from several dendrites to an axon. A wealth of recent studies has shown that PI 3-kinase, Rho family GTPases, the Par complex, and cytoskeleton-related proteins participate in the initial even...
متن کاملNeuronal Polarity and Neurological Disorders
Neuronal cell function is largely dependent on polarity. Studies in the past decades indicate that the neuronal polarity machinery is one of the major targets of neurological disorders. Planar cell polarity (PCP) and apicobasal (AB) polarity modules were shown to be crucial for the establishment of neuronal polarity. Accordingly, neural tube defects (NTDs) have been associated with mutations in...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(01)80021-0